Literal translation: "The greatest bondage of people often comes from themselves."
My translations: "The strongest chains of bondage are forged by the slaves themselves." "The strongest bondage is imposed by the slaves themselves." "Slaves are the greatest enslavers." "Slaves enslave themselves."
I understand the gist of the Chinese sentence, but it's hard to make a literal English statement sound natural.
My interpretations get the idea across, but are more poetic than probably you intended.
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