il mio cane sta perdendo peso. (In Italian we just use the masculine noun for both sexes because the feminine form "La cagna" is considered rude, since it has the same meaning of the English word "bitch". English people do the same and never say "bitch" when referring to a female dog, they just use "dog".
Otherwise, you could use the word "cagnolina", which is acceptable and literally means "little female dog".
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